San Francisco 49ers running back Christian McCaffrey and wide receiver Deebo Samuel have both been ruled out for the remainder of the team's Week 6 matchup against the Cleveland Browns on Sunday (October 15) due to injuries each player experienced earlier in the game.
McCaffrey was officially ruled out due to an oblique injury after initially being questionable for a return. The former All-Pro running back briefly returned from the injury earlier in the game before heading to the locker room to be observed, NFL Network's Tom Pelissero reported.
Samuel was officially ruled out after suffering a shoulder injury, NBC Sports Bay Area's Matt Maiocco reported.
Both injuries came after All-Pro left tackle Trent Williams suffered an ankle injury before ultimately returning to the game.
McCaffrey had scored a touchdown in every game of the 2023 NFL season, which included a 13-yard reception from Brock Purdy on the Niners' opening possession on Sunday. The former Stanford standout recorded 43 yards on 11 rushing attempts and three receptions for nine yards in Week 6.
Samuel was only targeted once before being pulled from Sunday's game. The former South Carolina standout entered Week 6 with 20 receptions for 302 yards and one touchdown, as well as 84 yards and one touchdown on 16 rushing attempts.
Jason Whitlock: Deion Sanders is Turning Son, Shedeur into Johnny Manziel
Jason Whitlock: Deion Cares More About Shedeur's Draft Stock Than Winning
Colin Cowherd: Brock Purdy is Better Than These NFL Quarterbacks
Colin Cowherd: It's Time For Patriots to Fire Bill Belichick
Police Aim to Charge Three Men in Death of Patriots Fan at Game
Charge Against Former NFL Player Sergio Brown in Mother's Death is Revealed
Colin Cowherd Says Jordan Love is a 'Backup Quarterback'
WATCH: Jason Kelce Goes on Anti-Turf Rant After His Brother’s Injury
Colin Cowherd Calls Out 'Delusional' Dak Prescott Supporters
Strange New Details Revealed on Incident That Led to Chandler Jones' Arrest